Officers were called to a report of a serious collision on the Hednesford Road near the Rugeley area at around 16:00.
The collision was between a grey Land Rover and a grey MG.
The driver of the MG, a man in his 40s, died at the scene.
His next of kin have been informed and are now being supported by specially trained officers.
The driver and passengers in the Land Rover were taken to a local medical facility for further checks, but a spokesperson from Staffordshire Police believes their injuries are minor.
Detectives from Staffordshire Police's Serious Collision Investigation Unit are at the scene and are now trying to establish the circumstances leading up to the collision.
Anyone who may have witnessed the collision or has dashcam footage of the incident should contact Staffordshire Police on 101 quoting Incident Number 510 of 22 March 2025.